Sustained release of amoxicillin from hydroxyapatite nanocomposite for bone infections
نویسندگان
چکیده
منابع مشابه
Hydroxyapatite/collagen bone-like nanocomposite.
Our group has succeeded to synthesize material with bone-like nanostructure and bone-like inorganic and organic composition via self-organization mechanism between them using simultaneous titration method under controlled pH and temperature. The hydroxyapatite/collagen (HAp/Col) bone-like nanocomposite completely incorporated into bone remodeling process to be substituted by new bone. Cells cul...
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The use of bioscaffolds for tissue repair is widely accepted. They can provide structural stability and a 3D system on which cells can grow new tissue. Natural bone is composed of organic (mainly collagen) and mineral biomaterials (predominantly carbonate hydroxyapatite, HA). In recent years, developments in 3D porous-scaffold manufacturing have increased hopes of successful fabrication of stru...
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Amoxicillin (α-amino-p-hydroxybenzyl-penicillin) is a semi-synthetic, orally absorbed and widely prescribed β-lactam antibiotic. It is now widely used for eradication of gastric Helicobacter pylori infection combined with a second antibiotic and an acid‐suppressing agent despite its short elimination half-life of one hour. The purpose of this study was to develop and evaluate amoxicillin loaded...
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Natural or synthetic hydroxyapatite (HA) has been frequently used as implant materials for orthopaedic and dental applications, showing excellent bioactivity, adequate mechanical rigidity and structure, osteoconductivity and angiogenic properties, no toxicity, and absence of inflammatory or antigenic reactions. HA can be easily synthesized or extracted from natural sources, such as bovine bone....
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Background: Inflammatory bone resorption in periodontitis can lead to tooth loss. Systemic administration of bisphosphonates such as risedronate for preventing bone resorption can cause adverse effects. Alginate hydrogel (ALG) and poly (lactic acid-co-glycolic acid) (PLGA) microparticles have been studied as drug delivery systems for sustained release of drugs. Therefore, the release pattern of...
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ژورنال
عنوان ژورنال: Progress in Biomaterials
سال: 2018
ISSN: 2194-0509,2194-0517
DOI: 10.1007/s40204-018-0103-4